TFB2M Antibody, FITC conjugated

1. Study reports crystal structures of human mitochondrial transcription initiation complexes assembled on both light and heavy strand promoters. The structures reveal how transcription factors TFAM and TFB2M assist mitochondrial RNA polymerase to achieve promoter-dependent initiation. PMID: 29149603
2. demonstrate that a complex composed of TFAM and POLRMT was readily formed at the promoter but alone was insufficient for promoter melting, which only occurred when TFB2M joined the complex PMID: 28028173
3. The results reveal the organization of TFAM, POLRMT and TFB2M around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex. PMID: 24413562
4. only two essential initiation factors, TFAM and TFB2M, and two promoters, LSP and HSP1, are required to drive transcription of the mitochondrial genome PMID: 20410300
5. The mRNA levels of TFB1M and TFB2M are influenced by endurance training PMID: 19681768
6. This transcription factor activates transcription of human mitochondrial DNA. PMID: 12068295
7. Distinct, but possibly coordinated functions of mtTFB1 and mtTFB2 in mitochondrial gene expression and biogenesis. PMID: 17557812
8. This study suggested that DNA variants in TFB2M did not contribute to the risk for parkinson disease. PMID: 18980857
9. determined the variation in the TFAM, TFB1M, and TFB2M genes in cardiac hypertrophy PMID: 19096125
10. rRNA methyltransferase activity is necessary for induction of mitochondrial biogenesis by TFB1M, but not TFB2M. PMID: 19417006
11. Promoter-independent DNA conformation-dependent transcription required TFB2M. PMID: 19624753

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HGNC: 18559

OMIM: 607055

KEGG: hsa:64216

STRING: 9606.ENSP00000355471

UniGene: Hs.7395